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Mucinex Products (Guaifenesin) Questions and Drug Interactions

CAUTION: All Mucinex products should be taken with plenty of water to reduce the thickness of secretions and chest congestion. Make sure all your health care providers have a complete list of your medications, including over-the-counter medications, herbals and vitamins.

Mucinex DM is first, followed by Mucinex, followed by Mucinex D.

I am taking Hydromet for a cough. Is it safe to take Mucinex DM or Mucinex D along with this medication?
There are no direct drug interactions between Hydromet (homatropine, hydrocodone) a narcotic cough suppressant and secretion drying agent, and either form of Mucinex (guaifenesin). If you have high blood pressure or heart conditions, I would avoid any oral decongestant without speaking to your doctor first.

Can I take Mucinex DM with isosorbide mononitrate?
There are no direct drug interactions between Mucinex DM (guaifenesin w/dextromethorphan) and isosorbide mononitrate (Imdur).

I might have taken a second dose of Mucinex Fast Max an hour after the first dose. What are the side effects if I doubled dosed?
As long as you do not take any more of this or other cold products, the main immediate issue you may notice would be a faster heart rate or jitters due to the phenylephrine.

Can I take Tylenol Cold Multi-Symptom 4 hours after taking Mucinex Maximum Strength?
If you have the plain Mucinex (guaifenesin), there would be no direct drug interactions, and this may be taken with Tylenol Cold Multi-Symptom. If you have the Mucinex D or Mucinex DM, then you should not take this with the Tylenol product, as there would be duplication of the cough suppressant or oral decongestant. Drink plenty of water with each of these products.

Can l take Afrin nose spray and maximum strength Mucinex Sinus and Cold syrup together?
You should avoid using Afrin (oxymetazoline) and Mucinex Sinus & Cold (guaifenesin, phenylephrine). Taking phenylephrine with the Afrin can increase the risk of high blood pressure, nervousness, palpitations or problems with sleep. You may take plain Mucinex with the Afrin. Do not use the Afrin more than twice a day and not longer than 2-3 days in a row.

Which Mucinex gets rid of only phlegm symptoms?
The plain Mucinex (guaifenesin) is the one you want. The normal dose is 1 tablet twice daily, and drink plenty of water while taking this medication.

Can I take Mucinex DM (guaifenesin/dextromethorphan), an expectorant/cough-suppressant combination, with:

Adderall and Lithium? Yes. Take Adderall (amphetamine salts) and lithium regularly at the same times each day. Take Mucinex DM as needed.
Advil (Ibuprofen)? Yes. Take both only as needed. Take Advil with food or milk.
Allegra (Fexofenadine)? Yes. Drink plenty of water. Take only as needed, unless your doctor has told you differently.
Allegra D (Fexofenadine with Pseudoephedrine)? Yes. Be sure you get Mucinex DM and not the D. Take only as needed. If you have high blood pressure or heart problems, talk to your doctor before taking Allegra D.
Benadryl (Diphenhydramine)? Yes. They may be taken together if needed. Take the Mucinex product with plenty of water. Benadryl can cause drowsiness, extreme in some cases. Take only when needed.
Cetirizine Hydrochloride (Zyrtec) and Pseudoephedrine Hydrochloride (Sudafed)? Yes. They should be taken only as needed, with plenty of water and may be taken together.
Cheratussin AC syrup? This is duplication of therapies. Do not take these together. Both use guaifenesin with a cough suppressant. Mucinex has dextromethorphan and Cheratussin AC has codeine. Take one or the other, only as needed, with plenty of water. Codeine may cause drowsiness and constipation; DM is much less likely to have this side effect.
Claritin (Loratadine)? Yes. Drink plenty of fluids. Use Tylenol, aspirin or an NSAID for fever or headache.
Claritin D (Loratadine with Pseudoephedrine)? Yes. These medications each contain two drugs that treat two different conditions. Mucinex DM is an expectorant/cough suppressant. Claritin D is an antihistamine decongestant. Avoid Claritin D if you have high blood pressure or heart problems. If you develop a fever, take Tylenol (acetaminophen) or Motrin (ibuprofen) with any of these.
Coumadin? Yes. Take Coumadin at the same time daily, and have your INR drawn when the doctor requests. Take Mucinex DM only as needed.
Darvocet? Yes. Darvocet can cause drowsiness. Take this only as needed.
Delsym (Dextromethorphan)? While there are no direct drug interactions between Mucinex DM and Delsym there is a duplication of ingredients. Both are time release and both contain dextromethorphan. So if you take 1 tablet of Mucinex DM and 1 teaspoonful (5cc) of Delsym twice a day, you would be at the maximum daily limit of the dextromethorphan.
Diclofenac? Yes. Take the anti-inflammatory diclofenac with food or milk and take both these for as long as your physician has instructed.
Flexeril (Cyclobenzaprine) Yes. Drink plenty of water with the Mucinex product. Take both only when needed.
Lisinopril 20/12.5, Zyrtec and Septra DS? Yes. Take lisinopril with HCTZ in the morning. Septra (sulfamethoxazole with trimethoprim) should be taken with plenty of water, like Mucinex and Zyrtec. Take lisinopril every day and Septra as long as instructed. Take Mucinex and Zyrtec as needed.
Lorazepam? Yes. Lorazepam can cause drowsiness.
Metformin (Glucophage), Synthroid (Levothyroxine) and Advil?
Yes. Take Synthroid 30 minutes before breakfast. Drink plenty of water with Mucinex DM. Take metformin with breakfast and dinner. Take Advil (ibuprofen) with food or milk.
NyQuil? Some types of NyQuil already have DM (dextromethorphan). If the NyQuil does not have DM, you may take them both together. NyQuil can cause drowsiness. Drink plenty of water with both.
Pamprin Multi-Symptom? Yes. They may be taken together if needed. Do not take Mucinex more than twice daily. Take both only as needed.
Paxil (Paroxetine) or Cymbalta (Fluvoxamine)? With Paxil, there could be dextromethorphan toxicity. Symptoms include nausea, vomiting, blurred vision, hallucinations. SSRI-type antidepressants such as Paxil interfere with dextromethorphan metabolism, which can lead to clinical toxicity that resembles the serotonin syndrome. Symptoms include hypertension, hyperthermia, myoclonus, mental status changes. Dextromethorphan should be used in lower doses in patients taking SSRIs, since it is a potent inhibitor of CYP2D6, the enzyme that metabolizes dextromethorphan. But Cymbalta does not appear to appreciably inhibit CYP2D6. It would be the safer choice. If you do not have a cough, you could use plain Mucinex to relieve congestion in the lungs. Only take Mucinex when needed. Take your Paxil or Cymbalta daily as directed by your physician. Do not stop taking, or alter the dose without instruction from the doctor.
Primatene Tablets? Primatene tablets contain ephedrine and guaifenesin. Taking this with Mucinex DM would be duplicating the expectorant, which may not be bad, if your chest is congested. The ephedrine would help open the lungs and sinuses, but can increase heart rate. If you have high blood pressure or heart problems, talk to your doctor before using Primatene.
Prozac (Fluoxetine)? No. Do not take Mucinex DM or any medication containing dextromethorphan (DM) while taking Prozac. It may result in dextromethorphan toxicity (nausea, vomiting, blurred vision, hallucinations) or serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes). Plain Mucinex (guaifenesin) is fine to take while you are taking Prozac. Drink plenty of water, do not stop taking Prozac and try a cough lozenge (without DM) for a cough. If you have chest congestion, plain Mucinex is what you want to take.
Robitussin Night Time Cough, Cold and Flu? No. This would cause multiple duplications of the same drug type. Mucinex DM is an expectorant and cough suppressant. Robitussin Night Time Cough,Cold and Flu has guaifenesin, dextromethorphan, acetaminophen, chlorpheniramine and pseudoephedrine. If you are having trouble with chest congestion and coughs, take Mucinex DM and drink plenty of water. If you have fever or flu-like symptoms, add plain Tylenol (acetaminophen) to the Mucinex. Adding moisture to the air can reduce the nasal congestion of a cold. A cool humidifier is best.
Sudafed? Yes. If you have high blood pressure or heart disease, please speak to your doctor before taking any oral nasal decongestant like Sudafed. Take the Mucinex product with plenty of water.
Sudafed Maximum Strength? Yes. If you have high blood pressure or heart problems, talk to your doctor before taking Sudafed. Drink plenty of water with both and only take as needed.
Sudafed PE? Yes. Take both with water. Sudafed products can increase blood pressure. If you have high blood pressure or heart problems, talk to your doctor before taking any nasal decongestant.
Tylenol Extra-Strength? Yes. The daily limit of acetaminophen is 3000mg -- 6 extra-strength tablets.
Tylenol PM (Acetaminophen with Diphenhydramine)? Yes. They may be taken together. Take Tylenol PM when you go to bed. Limit the amount of Tylenol per day to no more than 3000mg. Take Mucinex with plenty of water. Take both only as needed.
Tylenol PM Extra-Strength? Yes . . . as long as you are an adult without liver or prostate problems. Do not take these if you are unable to stay in bed for a full night's sleep. Be careful when you first get up, as you may not be as alert as normal. Take as needed.
Venlafaxine hcl (Effexor)?
Yes. They may be taken together. Take venlafaxine as prescribed. Never stop or change your dosage of this drug without instruction from your doctor. Take Mucinex with plenty of water.
Zoloft (Sertraline)? Yes. Take Mucinex only when needed. Do not stop taking Zoloft without instruction from your physician.
Zyrtec and Z-pak? Yes. Take the Z-pak (azithromycin) each morning until finished. Drink plenty of fluids with both Mucinex DM and Zyrtec (cetirizine), and take these as needed.
Zyrtec 10mg, Lasix 40mg and Advil 200-400mg?
Yes, but if you take Lasix (furosemide), a diuretic, too close to taking Advil (ibuprofen), an NSAID (nonsteroidal anti-inflammatory drug), the Advil can decrease the diuretic and antihypertensive effects of the Lasix. Take Advil at least 4-6 hours away from the Lasix, or take Tylenol (acetaminophen) with the Lasix.
Zyrtec D (Cetirizine with Pseudoephedrine)? Yes. Zyrtec takes care of the head and nasal symptoms. Mucinex takes care of the chest and cough problems. Drink plenty of water with both. Do not take Zyrtec D if you have high blood pressure. Take these as long as you have symptoms, unless otherwise instructed by your physician.

Can you take Advil Cold and Sinus, Mucinex DM, Zyrtec and Flonase together?
There is a possible, but minor drug interaction between the Advil Cold and Sinus (ibuprofen w/pseudoephedrine) and the Flonase (fluticasone). Side effects from ibuprofen such as stomach upset, nausea, or heartburn may get worse if you also take corticosteroids (like Flonase), especially if taken together for prolonged periods of time. The Mucinex DM ( guaifenesin w/dextromethorphan) and Zyrtec (cetirizine) are fine with the others.

Is Mucinex DM an anti-inflammatory drug?
Mucinex DM (guaifenesin with dextromethorphan) is a mixture of an expectorant with a cough suppressant. These are not an anti-inflammatory medications.

How long does it take for Mucinex DM to work for a cough?
Mucinex DM (guaifenesin with dextromethorphan) is a timed release tablet. The dextromethorphan is rapidly absorbed from the GI tract, with antitussive (anti cough) activity appearing within 15-30 minutes. Antitussive activity can last for 5-6 hours. Drink plenty of water with this product.

My doctor prescribed me tramadol (Ultram, Tramal) and Neurontin (gabapentin), and amitriptyline for fibromyalgia. Can I take those two medications with Mucinex DM? Or do I have to wait few hours before I take my prescribed medications?
There are two possible drug interactions with this group of medications. Both of these involve amitriptyline (Elavil). Taken with either the tramadol or Neurontin, the amitriptyline can cause more drowsiness, confusion, tremors and convulsions. The anticonvulsant actions and the antidepressant actions can be reduced by taking these together. Since you are taking these for a different condition (fibromyalgia), you most likely would not notice these issues. But if you take Neurontin to prevent seizures, talk to your physicians about this possible problem. Be prepared to notify your physician if you have problems. There is no problem with the Mucinex DM with any of the others. Drink plenty of water when taking Mucinex DM.

Does Mucinex DM contain a blood thinner?
Mucinex DM (guaifenesin with dextromethorphan) contains an expectorant and a cough suppressant. No blood thinner. Take it only as needed, and drink plenty of water with it.

Can I take Mucinex (guaifenesin) with:

Acetaminophen? Yes. Just like ibuprofen. You may take Mucinex with Motrin, Tylenol or aspirin.
Adderall?
Yes. They may be taken together if needed. Take Adderall as instructed and Mucinex as needed with plenty of water.
Adult Robitussin Nighttime Cough, Cold & Flu
There are no direct drug interactions, but there is a duplication of ingredients. Adult Robitussin Nighttime Cough, Cold and Flu (dextromethorphan, guaifenesin, chlorpheniramine, acetaminophen) has less guaifenesin than Mucinex (guaifenesin). This won't necessarily hurt you, but I recommend only taking medications for the symptoms you have. Drink plenty of water with both medications.
Alavert (Loratadine, Claritin)? Yes. They may be taken together. Drink plenty of water with both of these medications and take only as needed.
Aleve Sinus 12-Hour, Non-Drowsy? Yes, as long as it is plain Mucinex. Take Aleve with food or milk to avoid stomach upset.
Alka-Seltzer Plus (Acetaminophen, Chlorpheniramine and Phenylephrine)? Yes. Take only as needed. Drink plenty of water with the Mucinex. The Alka-Seltzer product has an antihistamine that can cause drowsiness; and a decongestant that should be avoided if you have high blood pressure or heart problems, unless allowed by your physician.
Allegra D? Yes. Allegra D (fexofenadine with pseudoephedrine) and Mucinex are frequently prescribed together. Mucinex is indicated for chest congestion. Allegra D is indicated for allergy symptoms, including sneezing, runny nose and eyes, and head congestion. They may be taken together. Drink plenty of water, and take both only as needed.
Allegra D 24-Hour? Yes, as long as it is plain Mucinex. Take these only as needed.
Amoxicillin and Ibuprofen? Yes. Amoxicillin, ibuprofen and Mucinex may be taken together.
Amoxicillin/Clavulanic Acid (Augmentin)? Yes. Drink plenty of water with Mucinex, and take the amoxicillin/clavulanic until gone with food or milk. Augmentin antibiotics can upset the GI tract. 
Benzonatate (Tessalon)? Yes. Take both with plenty of water and only as needed. The benzonatate can cause drowsiness, so avoid alcohol and be careful if you must be alert.
Benzonatate (Tessalon) and Atenolol (Tenormin)? Yes. They may be taken together if needed. Drink plenty of water with Mucinex.
Cephalexin (Keflex) and Claritin (Loratadine)? Yes. Take cephalexin until finished. Take Mucinex and Claritin as needed, with plenty of water.
Cephalexin (Keflex), Pseudo (Sudafed) and Zoloft (Sertraline)? Yes, as long as it is plain Mucinex, as there is also a version with the D (pseudoephedrine). Take cephalexin until the prescription is complete. Take Zoloft at the same time daily, and do not stop or change dose without direction of the doctor. Use Mucinex and pseudoephedrine only as needed. Avoid Sudafed if you have high blood pressure or heart problems.
Chemotherapy? Talk with your oncologist. Take your list of medications and discuss what, how and when to take your medications relative to the treatments.
Claritin D (Loratadine with Pseudoephedrine)? Yes. They may be taken together with plenty of water. If you have Mucinex D, it has the same decongestant (pseudoephedrine) as the Claritin D, so there would be a duplication of therapy.  If you have high blood pressure or heart problems, talk to your physician before taking any decongestant.
Comtrex Cold & Cough or Sinus Tabs? You may take Mucinex (the plain version) with any sinus, or cough and cold medication that does NOT have an expectorant (guaifenesin). Check the ingredient list. Drink plenty of fluids with any expectorant.
Coumadin? Yes. Take Mucinex only as long as needed.
DayQuil? Yes. Drink plenty of water with Mucinex. Only take these as needed. The oral decongestant warning applies to the Vicks DayQuil if you have high blood pressure or heart disease.
DayQuil Cold and Flu Multi-Symptom Relief? Yes but if you have high blood pressure or heart problems, talk to your doctor before taking DayQuil. Drink plenty of water, and take as needed.
Fexofenadine (Allegra)? Yes. Drink plenty of water with both.
Flexeril (Cyclobenzaprine)? Yes. They may be taken together if needed. Always take Mucinex with plenty of water. Flexeril can cause drowsiness. Take these only as needed.
Generic Sinus and Allergy pe (active ingredients chlorpheniramine maleate  and phenylephrine hcl)? Yes. If you have high blood pressure or heart problems, ask your physician before taking a decongestant like phenylephrine. Chlorpheniramine can cause drowsiness. All should only be taken as needed.
Hydrochlorothiazide (HCTZ) Yes.
Hydrocodone (Vicodin, Norco, Lorcet)? Yes. They may be take together if needed. Hydrocodone can cause drowsiness and stomach irritation. Take Mucinex with plenty of water. Take both only as needed.
Imodium?     Yes. They may be taken together. Take only as needed. Drink plenty of water with Mucinex. 
Levaquin (Levofloxacin)? Yes. Take Levaquin until finished with food.
Lexapro and Lamictal? Lexapro (escitalopram) and Lamictal (lamotrigine) taken together may result in an increased risk of myoclonus -- a brief, involuntary twitching of a muscle or a group of muscles. If you notice muscle twitches, pain or discomfort, contact your physician. It is unclear if taking these at different times or together makes any difference in the chance of this interaction. Mucinex is fine to take with either. Avoid alcohol. Do not stop taking Lexapro or Lamictal without consulting your physician. Take Mucinex as needed.
Lisinopril and Amlodipine? Yes, as long as it is plain Mucinex.
Losartan, Amiodarone HCL and Pravastatin? There is one slight drug interaction when taking these. Amiodarone can theoretically increase the actions of losartan. Although an interaction is possible, these drugs may be used together. If blood pressure drops too low while taking these medications, you may become dizzy or feel faint. To limit this interaction, do not stand or sit up too quickly. Notify your physician if dizziness continues. Take the Mucinex as needed, with plenty of water.
Losartan Potassium (Cozaar)? Yes. They may be taken together if needed. Drink plenty of water with the Mucinex.
Methimazole, Benicar, Simvastatin and Atenolol? Yes, but concurrent use of methimazole and beta blockers like atenolol (Tenormin) may result in increased clearance of beta-blockers. This would decrease the effectiveness of the atenolol. Discuss this with your physician.
Micardis (Telmisartan), Indocin (Indomethacin) and Vitamin D (Ergocalciferol)? Although an interaction is possible, nonsteroidal anti-inflammatory drugs (NSAIDs) -- like Indocin -- and antihypertensive agents (drugs that reduce high blood pressure) -- like Micardis are often used together. Long-term NSAID use may decrease antihypertensive's ability control your blood pressure, especially in older patients. If you take NSAIDs and antihypertensives together for long periods, your health care provider may monitor your blood pressure to make sure it is well-controlled. If you check your own blood pressure at home and notice an increase in your blood pressure, contact your health care provider. There are no problems with Mucinex and Vitamin D with any of these drugs.
Motrin IB? Yes. Take the Motrin with food or milk.
Norvasc (Amlodipine), Coreg CR (Carvedilol) and Hydrochlorothiazide? Concurrent use of calcium channel blockers -- like Norvasc -- and beta-adrenergic blockers -- like Coreg -- may result in hypotension or bradycardia. Many times, several different classes of drugs are used to treat diseases at lower doses rather than using one drug alone. This can reduce the chances of side effects. If these are prescribed by the same doctor, you have been instructed to notify the physician of any ill effects. If they were prescribed by different doctors, make sure that each knows your complete medication profile. Take Mucinex as needed for chest congestion with plenty of water. Take the blood pressure medication and diuretic at the same time daily unless instructed otherwise by your physician.
NyQuil at night?
Yes. Drink plenty of water throughout the day when you're taking Mucinex. NyQuil can cause drowsiness. Take these only as long as needed.
Phenergan (Promethazine)? Yes. They may be taken together. Take each only as needed. Mucinex should be taken with plenty of water. Phenergan can cause drowsiness.
Robitussin, Quaelfinson and Pepcid? I am unfamiliar with Quaelfinson, but it sounds suspiciously like guaifenesin, which is the generic name for both Robitussin and Mucinex. There are no direct drug interactions between Pepcid (famotidine) and any type of guaifenesin. Do not take multiple forms of guaifenesin unless instructed by your physician. Take with plenty of water and only as needed.
Robitussin CF and Tussionex? Taking Robitussin CF (dextromethorphan, guaifenesin and phenylpropanolamine) would be duplicating parts of both of the other drugs. There is no problem with the Tussionex (chlorpheniramine and hydrocodone) and Mucinex (guaifenesin). Both of these are long-acting medications and should be taken no more than twice daily. Use Tussionex and Mucinex and drink plenty of water. Use Mucinex D (not DM) if you need a sinus decongestant, but saline nasal spray is a safer decongestant.
Robitussin Cough DM? Do not use Robitussin and Mucinex at the same time. Both have guaifenesin as their active ingredient. Either Robitussin DM or Mucinex DM could be used for a cough with chest congestion. Drink plenty of fluids.
Singulair (Montelukast)? Yes. Mucinex is normally taken twice daily and Singulair once.
Sudafed (pseudoephedrine) Yes.
Toprol (Metoprolol)?
Yes. Be sure you only use plain Mucinex if you have high blood pressure or heart problems. Some forms of Mucinex have decongestants, which can raise blood pressure. Take Mucinex only as needed.
Tramadol (Ultram)? Yes. They may be taken together. Take Mucinex with plenty of water and tramadol as needed. Tramadol can cause drowsiness.
Tramadol (Ultram), Carisoprodol (Soma) and Hydrocodone? Yes. There are no direct drug interactions between Mucinex, tramadol and hydrocodone. They may be taken together. Take Mucinex with plenty of water and tramadol as needed. Tramadol and hydrocodone can cause drowsiness. Taking hydrocodone and carisoprodol may result in additive respiratory depression. Soma can cause drowsiness. Talk to your doctor.
Tramadol, Lunesta, Inderal, Zetia, Zantac and Flonase?
Yes. Take Lunesta (eszopiclone) as needed for sleep. Take Mucinex as needed. Take tramadol (Ultram) as needed for pain. This can cause drowsiness. The rest, take at the same times each day, and do not stop unless instructed by your physician.
Vicodin? Yes. Vicodin can cause drowsiness.
Warfarin (Coumadin)?
Yes. Take warfarin the same time each day, and get your blood tested as often as the doctor tells you. Take Mucinex only as needed.
Xanax (Alprazolam), Prevacid (Lansoprazole) and a multivitamin? Yes. Take Xanax as needed. It can cause drowsiness. Take the vitamin with breakfast to prevent stomach upset. Take Mucinex as needed. Prevacid is best taken before the largest meal of the day on a regular basis.
Zyrtec (Cetirizine) Yes. If you have high blood pressure or heart problems, please speak to your physician before taking any oral decongestants.
Zithromax? Yes. Mucinex is the same drug as Robitussin, just a different strength. Guaifenesin and Zithromax (azithromycin) may be taken together.
Zoloft (Sertraline)? Yes. They may be taken together. Take Mucinex with plenty of water.

Does Mucinex contain any sulfa drugs?.
Mucinex (guaifenesin) does not contain any sulfa, and is not related in any way to sulfa.

Can I take Mucinex with my blood thinner?
You do not indicate what blood thinner you are taking. In today's world, there are several medications that are used to "thin the blood." No matter which, none of these individually have any direct drug interaction with Mucinex (guaifenesin). Do not change how you take your blood thinner and only take the Mucinex when needed with plenty of water. Whenever you are taking blood thinning medications, be sure to inform all of your health care providers. It is also a good idea to carry a card or wear something to indicate you are taking blood thinning medication.

Does Mucinex have antihistamine in it?
The Mucinex brand is not combined with an antihistamine.

Is it OK to take Mucinex, Lodrane, and NyQuil together?
The Mucinex (guaifenesin) may be taken with either of the other products. This should be taken as needed with plenty of water. The Lodrane (brompheniramine) and NyQuil should not be taken together. Both medications have antihistamines. Depending on your symptoms, you may take either with the Mucinex but not both.

Is Mucinex safe to take one week before a surgery?
Yes. There is no cause for concern regarding surgery. But guaifenesin may alter some laboratory tests. Quite often, tests are done prior to surgery. I would suggest stopping Mucinex 48 hours prior to any pre-surgery tests or 48 hours prior to the day of surgery. When taking Mucinex, drink plenty of water.

Can guaifenesin or dextromethorphan have a diuretic effect?
Neither dextromethorphan (DM) or guaifenesin (Mucinex) list diuresis as a side effect. There are many causes for having a diuretic effect. Contact your physician if this continues.

I take tramadol 50mg, cyclobenzaprine 10mg, and Lipitor 20mg a day. Is it OK to take Mucinex with it?
The only potential problem is between the tramadol and cyclobenzaprine. You may feel drowsy or more tired when taking these drugs together. If you notice slurred speech, confusion, severe weakness, or difficulty breathing, contact your health care provider immediately.
Take the tramadol, cyclobenzaprine and Mucinex only as needed. Drink plenty of water with the Mucinex.

Can I take Mucinex D (guaifenesin with pseudoephedrine) with:

Abilify (Aripiprazole)? Yes. Take Mucinex D with plenty of water, as needed. If you have high blood pressure or heart problems, talk to your doctor before taking Mucinex D.
Adipex (Phentermine)? Yes. If you have high blood pressure or heart problems, talk with your doctor before taking either of these medications. Drink plenty of water with Mucinex.
Aleve (Naproxen)? Yes. Take both only as needed. Take Aleve with food or milk to avoid stomach upset. If you have high blood pressure or heart problems, talk to your doctor before taking Mucinex D. Decongestants should be avoided with any heart problems. Take plain Mucinex instead.
Allegra (Fexofenadine)? Yes. Drink plenty of water, and if you have high blood pressure or heart problems, talk to your doctor before taking any decongestant (pseudoephedrine).
Ambien? Yes. If you have heart problems or high blood pressure, talk to your doctor before taking any oral decongestant like pseudoephedrine. This part of the Mucinex D can cause your blood pressure to increase and may also keep you awake. If you need an expectorant at bedtime, take plain Mucinex with Ambien, that you should take only as needed.
Amitriptyline (Elavil)? In certain susceptible people, the "pressor response" -- the amount of vascular constriction -- of pseudoephedrine can be greatly enhanced by drugs like amitriptyline. This can be particularly harmful to those with high blood pressure or heart disease. If you have blood pressure or heart issues, talk speak to your physician before taking any oral decongestant. Plain Mucinex would be fine with amitriptyline. Drink plenty of water with Mucinex. Amitriptyline can cause drowsiness.
Amoxicillin?
Yes. You may take Mucinex D with any antibiotic. Take amoxicillin until finished.
Antihistamine (clemastine fumarate , USP 1.34) or any other antihistamine?
Yes. There are no direct drug interactions between Mucinex D and any antihistamine, including clemastine (Tavist). Make sure the antihistamine is not in combination with any other drug. Drink plenty of fluids. Most antihistamines can cause drowsiness.
Azithromycin (Zithromax), Doxycyline (Vibramycin), Medrol (methylprednisolone) and a multivitamin? Yes, but there are specific times when some of these should be taken. The decongestant in Mucinex D can keep you from sleeping, so do not take it near bedtime. Take azithromycin in the morning before breakfast. Take doxycycline an hour before or two hours after meals (avoid antacids with this drug). Medrol, if not in the package with specific dosing instructions, is normally given in the morning with or after breakfast. This prevents stomach upset and mimics the body's normal steroid levels. You listed multivitamin, and this answer is based on a multiple vitamin without minerals or other additives. If your vitamin has minerals such as calcium or iron, avoid taking it with the antibiotics (azithromycin and doxycycline). Take the antibiotics and Medrol as instructed for the complete duration as prescribed.
Benadryl? Yes. Drink plenty of water. Benadryl can cause drowsiness.
Celebrex? Yes. Take the Celebrex with or after food.
Cefprozil? Yes.
Claritin (Loratadine)? Yes. Be sure you have plain loratadine, as some formulas include a decongestant, which would duplicate the D part of the Mucinex. If you have heart problems or high blood pressure, talk to your doctor before taking decongestants. Drink plenty of water and only take as needed.
Claritin D 12-hour? Yes, 12 hours apart, however, do not take any decongestant if you have high blood pressure or heart problems without talking to your doctor. Claritin D is an antihistamine (loratadine) with the decongestant (pseudoephedrine). If you are only congested in the head, you do not need the Mucinex (guaifenesin) part. All you need is a decongestant like Sudafed 12-hour. This only has the decongestant.
Clonazepam? Yes. If you are taking clonazepam for sleep or to help calm you, the decongestant in the Mucinex D could decrease those effects. If you are not congested in the head, take plain Mucinex. Drink plenty of water.
Coumadin?
Yes. Take warfarin at the same time each day. Most doctors recommend that this be taken in the evening.
Cymbalta? Yes. If you have heart problems or high blood pressure, talk to you doctor before taking Mucinex D. The decongestant can cause constriction of the blood vessels and cause pressure to rise. Take Cymbalta every day as instructed, and do not stop this drug without the advice of the prescribing physician.
DayQuil No. Both products have an oral decongestant which could cause cardiac side effect symptoms that could be quite troublesome. Take one or the other but not both.
Diclofenac sodium? Yes. There are no direct drug interactions between Mucinex D and the NSAID (nonsteroidal anti-inflammatory drug) diclofenac (Voltaren, Cataflam). Don't use the D version of Mucinex if you have high blood pressure, unless instructed by your physician. Take diclofenac with food or milk to avoid stomach upset.
Hydroxyzine (Atarax) and Hydrocodone-Acetaminophen (Vicodin, Norco, Lortab)? There can be an increase in the side effect of drowsiness when taking these three. You may feel drowsy or more tired when taking these drugs together. Do not drive or operate machinery until you know how these drugs affect you. If you notice slurred speech, confusion, severe weakness or difficulty breathing, contact your health care provider immediately. Mucinex D may be taken with both the others.
Ibuprofen (Advil, Motrin)? Yes. Take each only as needed. Drink plenty of water with both and take the ibuprofen with food. If you have high blood pressure or heart problems, talk to your doctor before taking any product with a decongestant, like the Mucinex D.
NyQuil? No. Both have pseudoephedrine included in their formulas. Taking stimulant drugs like pseudoephedrine (Sudafed) may increase the risk of high blood pressure, nervousness, palpitations, problems with sleep or other serious side effects. Talk to your doctor before taking either of these drugs if you have high blood pressure or heart disease. Always treat only the symptoms you are having. Have your pharmacist assist in picking the correct product for your condition.
Phentermine 37.5? I do not recommend any diet pill, but there are no drug interactions between these products. Read up on the problems of Fen-Phen.
Synthroid (Levothyroxine)? Yes. Take Synthroid before breakfast, and drink plenty of water while taking Mucinex D. Take Mucinex only as needed.
Tylenol 3 (Acetaminophen with Codeine)? Yes. Take both only as needed. Limit Tylenol to 3000mg per day. Codeine can cause drowsiness, upset the stomach and cause constipation. If you have high blood pressure or heart problems, take plain Mucinex.
Tussionex oral suspension? Yes. They may be taken together. Take only as needed. Tussionex can cause drowsiness.
Wellbutrin XL? Yes. Mucinex is normally taken twice daily and with plenty of water throughout the day. Take Wellbutrin XL at the same time each day.
Zyrtec D? No. They both use pseudoephedrine (Sudafed) for a decongestant. Use plain Mucinex (guaifenesin) or plain Zyrtec (cetirizine) with the D form of the other. If you have high blood pressure or heart problems, talk to your doctor before taking any decongestant, which can cause an increase strain on the heart and an increase in blood pressure. Drink plenty of water with these.

I have been taking Mucinex D for 5 days and my last dose was 10 hours ago. How long do I need to wait if I want to switch to NyQuil Cold and Flu?
You should wait at least 12 hours before taking the Vicks Nyquil product. The Nyquil products have several different formulations, some of which
contain oral decongestants like pseudoephedrine or phenylephrine. Taking these over a long period of time can be problematic if you have high blood pressure or heart disease. Drink plenty of water with each of these medications and only take when needed.

Can I take levofloxacin, benzonatate and Mucinex D for my cold, cough and congestion?
Yes. If you have heart problems or high blood pressure, please speak to your physician before taking any oral decongestant like pseudoephedrine.

Can you take Mucinex D, cephalexin and Robitussin at the same time?
Technically there are no direct drug interactions between these medicines. But the Mucinex and Robitussin are the same drug. The cephalexin antibiotic should be taken until finished and may be given with either or both of the others.

Can I take Mucinex Cold & Sinus with lithium, Klonopin and Lamictal?
Yes. Take the Mucinex product with plenty of water and only as needed. Take the others just as prescribed by the physician.

Is it safe to take Singulair 10mg with Mucinex mini-melts?
Yes. There are no direct drug interactions between Singulair (montelukast) and Mucinex (guaifenesin). They may be taken together if needed.  Drink plenty of water with the Mucinex.

Does Mucinex contain aspirin or anything to cause blood thinning?
Mucinex (guaifenesin) is an expectorant. It does not cause thinning of the blood, only thinning of the lung secretions (mucous). Take Mucinex with plenty of water.

 
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